Polygenicity of Comorbid Depression in Multiple Sclerosis.

Kaarina Kowalec Kathryn C Fitzgerald Salter AmberCasandra DolovichArvid HarderCharles N BernsteinJames BoltonGary R CutterLesley A GraffSara HäggCarol Ann HitchonYi LuFred LublinKyla A McKayScott Burton PattenAmit PatkiHemant K TiwariJerry S WolinskyRuth Ann Marrie

Published in: Neurology (2023)

Higher depression genetic burden was associated with ∼30-40% increased odds of depression in European genetic ancestry participants with MS compared to those without depression and was no different compared to those with depression and no comorbid immune disease. This study paves the way for further investigations into the possible use of PGS for assessing psychiatric disorder risk in MS and its application to non-European genetic ancestries.

Keyphrases

multiple sclerosis
depressive symptoms
sleep quality
mass spectrometry
mental health
ms ms
gene expression
genome wide
copy number
risk factors