The extent of CYP3A Induction by Antiseizure Medications: A Systematic Review and Network Meta-Analysis.

Hagar CohenGhadeer MahajnaTomer Ben-ShushanIlan MatokSara Eyal

Published in: Epilepsia (2023)

Despite the limited number of studies, our NMA emphasizes that the magnitude of ASM effects on CYP3A substrate metabolism is a dose-dependent continuum. When possible, ASM classification as inducers should apply cutoff values tailored to the outcome. Prescribers should monitor plasma concentrations or clinical effects of CYP3A substrates and consider selecting concomitant medications accordingly.

Keyphrases

machine learning
deep learning
smoking cessation
case control
structural basis