Rapid spread of mannan to the immune system, skin and joints within 6 hours after local exposure.
Cecilia Fahlquist HagertR SiitonenX-G LiH LiljenbäckA RoivainenR HolmdahlPublished in: Clinical and experimental immunology (2019)
Psoriasis (Ps), psoriatic arthritis (PsA) and rheumatoid arthritis (RA) are common diseases dependent on environmental factors that activate the immune system in unknown ways. Mannan is a group of polysaccharides common in the environment; they are potentially pathogenic, because at least some of them induce Ps-, PsA- and RA-like inflammation in mice. Here, we used positron emission tomography/computed tomography to examine in-vivo transport and spread of mannan labelled with fluorine-18 [18 F]. The results showed that mannan was transported to joints (knee) and bone marrow (tibia) of mice within 6 h after intraperitoneal injection. The time it took to transport mannan, and its presence in blood, indicated cellular transport of mannan within the circulatory system. In addition, mannan was filtered mainly through the spleen and liver. [18 F]fluoromannan was excreted via kidneys, small intestine and, to some extent, the mouth. In conclusion, mannan reaches joints rapidly after injection, which may explain why mannan-induced inflammatory disease is targeted to these tissues.
Keyphrases
- positron emission tomography
- computed tomography
- rheumatoid arthritis
- prostate cancer
- bone marrow
- oxidative stress
- disease activity
- mesenchymal stem cells
- magnetic resonance imaging
- pet imaging
- gene expression
- pet ct
- systemic lupus erythematosus
- ankylosing spondylitis
- magnetic resonance
- radical prostatectomy
- high fat diet induced
- knee osteoarthritis
- skeletal muscle
- endothelial cells
- high glucose
- cancer therapy
- diabetic rats
- extracorporeal membrane oxygenation
- drug induced
- contrast enhanced
- wild type