Risk prediction in early childhood SHH medulloblastoma treated with radiation-avoiding chemotherapy: Evidence for more than two subgroups.

Svenja TonnAndrey KorshunovDenise ObrechtMartin SillMichael SpohnKatja von Hoff Till MildeTorsten PietschTobias GoschzikBrigitte BisonBjörn-Ole JuhnkeNina StruveDominik SturmFelix SahmMichael BockmayrCarsten FriedrichAndré O von BuerenNicolas U GerberMartin BeneschDavid T W JonesMarcel KoolAnnika K WefersUlrich SchüllerStefan M PfisterStefan RutkowskiMartin Mynarek

Published in: Neuro-oncology (2023)

These data suggest further heterogeneity within early childhood SHH-DMB/MBEN: SHH-2 splits into a very low-risk group SHH-2a enriched for MBEN histology and SMO mutations, and SHH-2b comprising older DMB patients with higher risk of relapse.

Keyphrases

physical activity
big data
radiation therapy
locally advanced
deep learning
rectal cancer