ATM mutations improve radio-sensitivity in wild-type isocitrate dehydrogenase-associated high-grade glioma: retrospective analysis using next-generation sequencing data.

Nalee KimSe Hoon KimSeok-Gu KangJu Hyung MoonJaeho ChoChang-Ok SuhHong In YoonJong Hee Chang

Published in: Radiation oncology (London, England) (2020)

Our results demonstrated that ATM mutations might be involved in the increased radio-sensitivity with excellent in-field control despite the aggressive nature of IDH-wildtype high-grade glioma. Further studies are necessary to uncover the potential role of ATM as a biomarker and candidate therapeutic target in high-grade gliomas.

Keyphrases

high grade
wild type
low grade
dna damage
dna repair
dna damage response
electronic health record
big data
risk assessment
gene expression
case control
human health
data analysis
artificial intelligence
cell free