Ubiquitin specific peptidase 37 and PCNA interaction promotes osteosarcoma pathogenesis by modulating replication fork progression.
Ravi ChauhanAshna GuptaLakshay MalhotraAjaz A BhatRaj K PanditaTariq MasoodiGunjan DagarHana Q SadidaSara K Al-MarzooqiAtul BatraSameer BakhshiMehar Chand SharmaPranay TanwarShah Alam KhanEthayathulla Abdul SamathShahab UddinAmmira S Al-Shabeeb AkilMohammad HarisMuzafar A MachaTej K PanditaMayank SinghPublished in: Journal of translational medicine (2023)
The results of this investigation propose that USP37 plays a vital role in promoting replication stress tolerance in osteosarcoma cells. The interaction between USP37 and PCNA is involved in the regulation of replication stress, and disrupting it could potentially trigger synthetic lethality in osteosarcoma. This study has expanded our knowledge of the mechanism through which USP37 regulates replication stress, and its potential as a therapeutic target in osteosarcoma merits additional exploration.