The down-regulation of XBP1, an unfolded protein response effector, promotes acute kidney injury to chronic kidney disease transition.

Jia-Huang ChenChia-Hsien WuJia-Rong JhengChia-Ter ChaoJenq-Wen HuangKuan-Yu HungShing-Hwa LiuChih-Kang Chiang

Published in: Journal of biomedical science (2022)

The loss of XBP1 in kidney injury was profibrotic, and the process was mediated by autocrine and paracrine regulations in combination. The present study identified the XBP1-Trap1 axis as an instrumental mechanism responsible for post-AKI fibrosis, which is a novel regulatory pathway.

Keyphrases

acute kidney injury
chronic kidney disease
cardiac surgery
end stage renal disease
dendritic cells
endoplasmic reticulum stress
regulatory t cells
protein protein
binding protein