Forkhead box (FOX) G1 promotes hepatocellular carcinoma epithelial-Mesenchymal transition by activating Wnt signal through forming T-cell factor-4/Beta-catenin/FOXG1 complex.

Xingrong ZhengJiaxin LinHewei WuZhishuo MoYunwen LianPeipei WangZhaoxia HuZhiliang GaoLiang PengChan Xie

Published in: Journal of experimental & clinical cancer research : CR (2019)

The results show that FOXG1 plays a key role in mediating cancer cell metastasis through the Wnt/β-catenin pathway in HCC cells and predicts HCC prognosis after surgery. Targeting FOXG1 may provide a new approach for therapeutic treatment in the future.

Keyphrases

epithelial mesenchymal transition
cell proliferation
signaling pathway
induced apoptosis
transcription factor
stem cells
transforming growth factor
cell cycle arrest
cancer therapy
oxidative stress
endoplasmic reticulum stress
cell death
combination therapy