10-year frailty trajectory is associated with Alzheimer's dementia after considering neuropathological burden.

Lindsay M K WallaceOlga TheouJudith GodinDavid D WardMelissa K AndrewDavid A BennettKenneth Rockwood

Published in: Aging medicine (Milton (N.S.W)) (2021)

Findings suggest a strong link between health status (frailty index) and dementia, even after considering neuropathology. Frailty trajectories were associated with risk for MCI and dementia, underscoring the importance of addressing frailty to manage dementia risk.

Keyphrases

mild cognitive impairment
cognitive decline
cognitive impairment
community dwelling
depressive symptoms
risk factors