Inhibition of glycogen synthase kinase 3β protects liver against ischemia/reperfusion injury by activating 5' adenosine monophosphate-activated protein kinase-mediated autophagy.

Defu KongXiangwei HuaTian QinJianjun ZhangKang HeQiang Xia

Published in: Hepatology research : the official journal of the Japan Society of Hepatology (2018)

Autophagy was induced by GSK3β inhibition through the AMPK/mTOR pathway and could substantially ameliorate liver I/R injury. Therefore, our findings strongly renew the therapeutic value of the GSK3β/autophagy axis in hepatic I/R injury.

Keyphrases

signaling pathway
protein kinase
cell death
oxidative stress
endoplasmic reticulum stress
ischemia reperfusion injury
pi k akt
cell proliferation