Spatial extent as a sensitive amyloid-PET metric in preclinical Alzheimer's disease.
Michelle E FarrellEmma G ThibaultJ Alex BeckerJulie C PriceBrian C HealyBernard J HanseeuwRachel F BuckleyHeidi I L JacobsAaron P SchultzCharles D ChenReisa A SperlingKeith A JohnsonPublished in: Alzheimer's & dementia : the journal of the Alzheimer's Association (2024)
Aβ spatial extent (EXT) was measured as the percentage of the neocortex with elevated Pittsburgh Compound-B. Aβ EXT improved detection of Aβ below traditional PET thresholds. Early regional Aβ deposits were spatially heterogeneous. Cognition and tau were more closely tied to Aβ EXT than Aβ level. Neocortical tau onset aligned with reaching widespread neocortical Aβ.