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Interferon-Driven Immune Dysregulation in Common Variable Immunodeficiency-Associated Villous Atrophy and Norovirus Infection.

Valentina StrohmeierGeoffroy AndrieuxSusanne UngerAnna Pascual-ReguantAdam KlocperkMaximilian SeidlOtavio Cabral MarquesMarleen EckertKatja GräweMichelle ShabaniCaroline von Spee-MayerDavid FriedmannIna HarderSylvia GutenbergerBaerbel KellerMichele ProiettiAlla BulashevskaBodo GrimbacherJan ProvaznikVladimir BenesSigune GoldackerChristoph SchellAnja E HauserMelanie BoerriesPeter HasselblattKlaus Warnatz
Published in: Journal of clinical immunology (2022)
Our study suggests that increased IFN signaling and T-cell cytotoxicity are present already in mild and are aggravated in severe stages (VA) of CVID enteropathy. NV infection preempts local high IFN-driven inflammation, usually only seen in VA, at milder disease stages. Thus, revealing the impact of different drivers of the pathological mixed IFN type I/III and II signature may allow for more targeted treatment strategies in CVID enteropathy and supports the goal of viral elimination.
Keyphrases
  • dendritic cells
  • immune response
  • oxidative stress
  • sars cov
  • cancer therapy