Adult vascular dysfunction in foetal growth-restricted guinea-pigs is associated with a neonate-adult switching in Nos3 DNA methylation.

Bernardo J KrauseEstefanía PeñalozaAlejandro CandiaDaniel CañasCherie HernándezGerman A ArenasMaría José Peralta-ScholzRodrigo ValenzuelaClaudio García-HerreraEmilio A Herrera

Published in: Acta physiologica (Oxford, England) (2019)

Altogether, these data suggest that adult vascular dysfunction in the FGR does not result from early changes in Nos3 promoter DNA methylation, but from an altered vessel structure established during foetal development.

Keyphrases

dna methylation
gene expression
genome wide
oxidative stress
nitric oxide synthase
childhood cancer
nitric oxide
electronic health record
big data
gestational age
young adults
artificial intelligence
preterm birth