FBW7 Regulates the Autophagy Signal in Mesangial Cells Induced by High Glucose.

Chenlin GaoFang FanJiao ChenYang Long Shi TangChunxia JiangYong Xu

Published in: BioMed research international (2019)

FBW7 was decreased in renal mesangial cells induced by high glucose, and FBW7 gene overexpression can increase autophagy by inhibiting mTOR signaling and ameliorate inflammation and fibrosis.

Keyphrases

high glucose
endothelial cells
induced apoptosis
endoplasmic reticulum stress
oxidative stress
signaling pathway
cell cycle arrest
cell death
gene expression
dna methylation