Login / Signup

Limited emergence of resistance to integrase strand transfer inhibitors (INSTIs) in ART-experienced participants failing dolutegravir-based antiretroviral therapy: a cross-sectional analysis of a Northeast Nigerian cohort.

Adam AbdullahiIbrahim Musa KidaUmar Abdullahi MainaAmina Husaini IbrahimJames MsheliaHaruna WissoAbdullahi AdamuJames Ezenwa OnyemataMartin EdunHaruna YusuphSani H AliyuMan CharuratAlash'le AbimikuLucie Abeler-DornerChristophe FraserDavid Bonsallnull nullSteven A KempRavindra Kumar Gupta
Published in: The Journal of antimicrobial chemotherapy (2023)
This study found a low prevalence of resistance to dolutegravir; the data are therefore supportive of the continual rollout of dolutegravir as the primary first-line regimen for ART-naive participants and the preferred switch to second-line ART across the region. However, population-level, longer-term data collection on dolutegravir outcomes are required to further guide implementation and policy action across the region.
Keyphrases