ART714 is a best-in-class antileukemic 2-carbon-linked dimeric artemisinin derivative.
Amanda B KaganBlake S MosesRena LapidusBryan T MottGanesha RaiNicole M AndersStephen W HoagMichelle A RudekCurt I CivinPublished in: Cancer chemotherapy and pharmacology (2023)
We identified ART714 as our best-in-class antileukemic 2C-ART, based on in vitro potency and pharmacologic properties. We established its in vivo pharmacokinetics and demonstrated its in vitro cooperativity with VEN and SOR and in vivo activities of combinations of ART714, VEN, and GILT. Additional research is indicated to define the optimal niche for the use of ART714 in treatment of AML.