Determination of permissive and restraining cancer-associated fibroblast (DeCAF) subtypes.

Xianlu Laura PengElena V KharitonovaYi XuJoseph F KearneyChangfei LuanPriscilla S ChanArthi HariharanIan C McCabeJohn R LearyAshley B MorrisonHannah E TrembathMichelle E LaBellaSilvia G Herera LoezaAshley CliffHong Jin KimBrian A BeltRoheena Z PanniDavid C LinehanJeffrey S DamrauerAlina C IugaWilliam Y KimNaim U RashidJen Jen Yeh

Published in: bioRxiv : the preprint server for biology (2024)

We introduce a replicable and robust classifier, DeCAF, that delineates the significance of the role of permissive and restraining CAF subtypes in cancer patients. DeCAF is clinically tractable, prognostic and predictive of treatment response in multiple cancer types and lays the translational groundwork for the preclinical and clinical development of CAF subtype specific therapies.

Keyphrases

papillary thyroid
squamous cell
cell therapy
solid phase extraction
molecularly imprinted
squamous cell carcinoma
stem cells
lymph node metastasis
young adults
bone marrow
high resolution