Reversibility of Cognitive Deficits and Functional Connectivity With Transfusion in Children With Sickle Cell Disease.

Landon C PowerAmy E MirroMicahel M BinkleyJinli WangKristin P GuilliamsJosiah B LewisAndria L Ford Joshua S Shimony Hongyu AnJin-Moo LeeMelanie E Fields

Published in: Neurology (2024)

Strengthening of functional connectivity with concomitant improvement in executive function abilities with transfusion suggests that functional connectivity MRI could be used as a biomarker for acutely reversible neurocognitive injury as novel therapeutics are developed for people with SCD.

Keyphrases

functional connectivity
resting state
cardiac surgery
magnetic resonance imaging
young adults
sickle cell disease
contrast enhanced
small molecule
bipolar disorder
diffusion weighted imaging