Poly(ethylene glycol)-mediated mineralization of metal-organic frameworks.

Qun Yu Yuan TianMeng LiYuan JiangHaifeng Sun Guiqiang Zhang Zhiliang GaoWei ZhangJingcheng Hao Ming Hu Jiwei Cui

Published in: Chemical communications (Cambridge, England) (2020)

We report a one-pot approach for the scalable synthesis of zeolitic imidazolate framework-8 nanoparticles (ZIF-8 NPs) using poly(ethylene glycol) as the mineralizer, where drugs and proteins can be encapsulated in the ZIF-8 NPs for intracellular delivery. The ZIF-8 NPs exhibit high colloidal dispersity and stability (above two weeks) in cell medium.

Keyphrases

metal organic framework
oxide nanoparticles
single cell
cell therapy
stem cells
bone marrow