Chimeric antigen receptors of HBV envelope proteins inhibit hepatitis B surface antigen secretion.
Yang WangQiqi LiCheng LiCong WangShijie WangWenjie YuanDemin YuKe ZhangBisheng ShiXiaomei ChenTiantian LiuZhenghong YuanShuping TongMichael NassalYu-Mei WenYong-Xiang WangPublished in: Gut (2023)
CARs possess direct antiviral activity, besides the well-known application in T-cell therapy. Fc attached G12-scFv and G12-CARs could provide a novel approach for reducing circulating HBsAg.