Simvastatin Prevents Liver Microthrombosis and Sepsis Induced Coagulopathy in a Rat Model of Endotoxemia.
Vincenzo la MuraNicoletta GaglianoFrancesca ArnaboldiPatrizia SartoriPatrizia ProcacciLuca DentiEleonora LiguoriNiccolò BittoGiuseppe RistagnoRoberto LatiniDaniele DondossolaFrancesco SalernoArmando TripodiMassimo ColomboFlora PeyvandiPublished in: Cells (2022)
Simvastatin preserves the antithrombotic properties of sinusoidal endothelial cells disrupted by LPS, deserving pharmacological properties to contrast sepsis-associated coagulopathy and hepatic failure elicited by endotoxemia.