Genotoxic and epigenotoxic effects in mice exposed to concentrated ambient fine particulate matter (PM2.5) from São Paulo city, Brazil.
Antonio Anax Falcão de OliveiraTiago Franco de OliveiraMichelle Francini DiasMarisa Helena Gennari MedeirosPaolo Di MascioMariana VerasMiriam LemosTania MarcourakisPaulo Hilário Nascimento SaldivaAna Paula de Melo LoureiroPublished in: Particle and fibre toxicology (2018)
Mice exposed daily to PM2.5 at a concentration that mimics 24-h exposure to the mean concentration found in ambient air presented, after 3 months, increased levels of DNA lesions related to the occurrence of oxidative stress in the lungs, liver, and kidney, in parallel to decreased global levels of 5-hmC in lung and liver DNA. Genetic and epigenetic alterations induced by pollutants may affect the genes committed to cell cycle control, apoptosis, and cell differentiation, increasing the chance of cancer development, which merits further investigation.
Keyphrases
- particulate matter
- air pollution
- cell cycle
- oxidative stress
- circulating tumor
- high fat diet induced
- cell proliferation
- genome wide
- cell free
- single molecule
- dna methylation
- papillary thyroid
- gene expression
- endoplasmic reticulum stress
- risk assessment
- dna damage
- physical activity
- cell death
- ischemia reperfusion injury
- insulin resistance
- type diabetes
- cell cycle arrest
- induced apoptosis
- copy number
- nucleic acid
- heavy metals
- diabetic rats
- skeletal muscle
- young adults
- lymph node metastasis