Cyclophilin A as a target in the treatment of cytomegalovirus infections.
Ashwaq A AbdullahRasedee AbdullahZeenathul A NazariahKrishnan N BalakrishnanFaez Firdaus J AbdullahJamilu Abubakar BalaMohd-Azmi Mohd-LilaPublished in: Antiviral chemistry & chemotherapy (2019)
Cyclosporin A has a dual function in cytomegalovirus pathogenesis. It has the immunosuppressive effect that establishes virus replication through the inhibition of T-cell function. It also has an anti-cytomegalovirus effect mediated by intermediate early protein 2. Both of these functions involve cyclophilin A pathway.