FoundationOne CDx testing accurately determines whole arm 1p19q codeletion status in gliomas.

Radwa SharafDean C PavlickGarrett M FramptonMaureen CooperJacqueline JenkinsNatalie DanzigerJames HaberbergerBrian M AlexanderTimothy CloughesyWilliam H YongLinda M LiauPhioanh L NghiemphuMatthew JiAlbert LaiShakti H RamkissoonLee A Albacker

Published in: Neuro-oncology advances (2021)

1p19q codeletion status derived from FoundationOne testing is highly concordant with FISH results. Genomic profiling may be a reliable substitute for traditional FISH testing while also providing IDH1/2 status.

Keyphrases

high grade
low grade
copy number
dna methylation
genome wide