KDM1A, a potent and selective target, for the treatment of DNMT3A-deficient non-small cell lung cancer.

Yingxi ZhaoYonghao ZhengJinjiang FuJiayu ZhangHui ShaoShougeng LiuJiacheng LaiXue ZhouRuijuan LiangLina JiaWei CuiJingyu YangChunfu WuLihui Wang

Published in: British journal of cancer (2024)

Our results provide new insight into the role of DNMT3A in NSCLC and elucidate the mechanism of synthetic lethal interaction between KDM1A and DNMT3A, which might represent a promising approach for treating patients with DNMT3A-deficient tumours.

Keyphrases

dna methylation
small cell lung cancer
gene expression
advanced non small cell lung cancer
wild type
epidermal growth factor receptor
brain metastases