Checkpoint inhibitor-expressing lentiviral vaccine suppresses tumor growth in preclinical cancer models.
Takuya TadaThomas D NortonRebecca LeibowitzNathaniel Roy LandauPublished in: Journal for immunotherapy of cancer (2024)
This study suggests that therapeutic vaccination that induces tumor antigen-specific CD8 T cells coupled with a vector-expressed checkpoint inhibitor can be an effective means to suppress the growth of tumors that are resistant to conventional immunotherapy.