A Meta-Analysis of the Antidepressant Responses in Pivotal Trials on Esketamine Nasal Spray and Atypical Antipsychotics.

Lien WangXiaowei ChenXiaojing GuHeidi De SmedtVanina PopovaDong-Jing FuCarla M CanusoWayne C DrevetsGuang Chen
Published in: Neuropsychiatric disease and treatment (2023)
The ESK-NS arms showed numerically larger MADRS score reductions at week-1 and endpoint, and a significantly larger response rate compared with AAP arms. Prospective studies involving direct comparisons are warranted to compare the relative efficacy between these treatment regimens.