Effects of Repeated Lysergic Acid Diethylamide (LSD) on the Mouse Brain Endocannabinoidome and Gut Microbiome.
Antonio InserraGiada GiorginiSebastien LacroixAntonella BertazzoJocelyn ChooAthanasios MarkopolousEmily GrantArmita AbolghasemiDanilo De GregorioNicolas FlamandGeraint RogersStefano ComaiCristoforo SilvestriGabriella GobbiVincenzo Di MarzoPublished in: British journal of pharmacology (2022)
The prosocial effects elicited by repeated LSD administration are accompanied by alterations of hippocampal eCBome and kynurenine levels, and the composition of the gut microbiota. Modulation of the hippocampal eCBome and kynurenine pathway might represent a mechanism by which psychedelic compounds elicit prosocial effects and affect the gut microbiome.
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