Metabolic Pathway of Osilodrostat in Equine Urine Established through High-resolution Mass Spectrometric Characterization for Doping Control.
Hideaki IshiiRyo ShigematsuShunsuke TakemotoYuhiro IshikawaFumiaki MizobeMotoi NomuraDaisuke ArimaHirokazu KuniiReiko YuasaTakashi YamanakaSohei TanabeShun-Ichi NagataMasayuki YamadaGary Ngai-Wa LeungPublished in: Current drug metabolism (2024)
It is advisable to screen for both osilodrostat and its mono-hydroxylated metabolite M1c to effectively monitor horse urine for the potential misuse or abuse of osilodrostat. For suspicious samples, confirmation of osilodrostat using its reference material is required.