In Vivo Electroporation-Mediated, Intrahepatic Alpha1 Antitrypsin Gene Transfer Reduces Pulmonary Emphysema in Pallid Mice.

Marco A SutterTiziana P CremonaIzabela NitaEleonora Cavarra Giuseppe Lungarella Eli C LewisJohannes C SchittnyThomas GeiserAmiq Gazdhar

Published in: Pharmaceutics (2020)

Our data indicate that in vivo intrahepatic electroporation-mediated gene transfer of AAT is a safe and efficient procedure resulting in reduction of pulmonary emphysema in pallid mice.

Keyphrases

pulmonary hypertension
chronic obstructive pulmonary disease
high fat diet induced
copy number
genome wide
lung function
genome wide identification
minimally invasive
insulin resistance
dna methylation
type diabetes
metabolic syndrome
wild type
skeletal muscle
air pollution
transcription factor
deep learning