Oxysterol derivatives Oxy186 and Oxy210 inhibit WNT signaling in non-small cell lung cancer.
Liu-Ya TangMarie SpeziaTing ChenJee-Hye ShinFeng WangFrank StappenbeckAndres M LebensohnFarhad ParhamiYing E ZhangPublished in: Cell & bioscience (2022)
The oxysterols Oxy186 and Oxy210 both possess inhibitory activity towards WNT/β-catenin signaling, and Oxy186 is also a potent inhibitor of NSCLC tumor growth.