SJPedPanel: A pan-cancer gene panel for childhood malignancies to enhance cancer monitoring and early detection.
Pandurang KolekarVidya BalagopalLi DongYanling LiuScott FoyQuang TranHeather L MulderAnna L W HuskeyEmily M PlylerZhikai LiangJingqun MaJoy NakitandweJiali GuMaria NamwanjeJamie L MaciaszekDebbie Payne-TurnerSaradhi MallampatiLu WangJohn EastonJeffery M KlcoXiaotu MaPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2024)
SJPedPanel enables the cost-effective detection of clinically relevant genetic alterations including rearrangements responsible for subtype-defining fusions by targeted sequencing of ~0.15% of human genome for childhood malignancies. It will enhance the analysis of specimens with low tumor burdens for cancer monitoring and early detection.
Keyphrases
- papillary thyroid
- childhood cancer
- squamous cell
- genome wide
- endothelial cells
- lymph node metastasis
- squamous cell carcinoma
- gene expression
- copy number
- dna methylation
- early life
- transcription factor
- cancer therapy
- loop mediated isothermal amplification
- real time pcr
- genome wide identification
- high throughput sequencing