Evaluation of major adverse events of clozapine based on accordance to an international titration guideline.
Matthew NuebelJonathan G LeungChristopher HughesIan R McGranePublished in: The mental health clinician (2024)
Based on our small retrospective review of primarily White males, more aggressive clozapine titrations did not increase ADRs. Future studies with more diverse samples are needed and should focus on specific ADRs, which may have increased occurrence with rapid titrations. Obese patients were at higher risk of ADRs, correlating with the guideline-recommended slower titrations for these patients.