Exercise-induced circular RNA circUtrn is required for cardiac physiological hypertrophy and prevents myocardial ischemia-reperfusion injury.

CircRNA circUtrn is required for the development of exercise-induced physiological cardiac hypertrophy. CircUtrn inhibition abolished the protective effects of exercise on I/R remodeling. Moreover, circUtrn overexpression prevented myocardial I/R-induced acute injury and pathological cardiac remodeling. Our findings suggest that circUtrn elevation and its protective role against I/R injury may hold a therapeutic promise in I/R injury and pathological cardiac remodeling.