Sarcoplasmic reticulum calcium ATPase (SERCA) proteolysis by matrix metalloproteinase-2 contributes to vascular dysfunction in early hypertension.
Marcela M Blascke de MelloViviano Gomes de Oliveira NevesJuliana Montenegro ParenteLaena PernomianIsadora Sousa de OliveiraCarina Amarante PedersoliWanessa Mayumi Carvalho AwataCarlos Renato TirapelliEliane Candiani ArantesRita de Cassia A TostesRichard SchulzMichele Mazzaron de CastroPublished in: European journal of pharmacology (2024)
doxycycline reduced MMP-2 activity in aortas of 2K-1C rats and prevented proteolysis of SERCA and its dysfunction, thus ameliorating hypertension-induced vascular dysfunction.