Inducibility, but not stability, of atrial fibrillation is increased by NOX2 overexpression in mice.
Alexandra S MighiuAlice RecaldeKlemen ZibernaRicardo CarnicerJakub TomekGil BubAlison C BrewerSander VerheuleAjay M ShahJillian N SimonBarbara CasadeiPublished in: Cardiovascular research (2022)
Together, these data indicate that while atrial NOX2 overexpression may contribute to atrial arrhythmogenesis, NOX2-derived superoxide production does not affect the electrical and structural properties of the atrial myocardium.
Keyphrases
- atrial fibrillation
- catheter ablation
- left atrial
- reactive oxygen species
- oral anticoagulants
- cell proliferation
- left atrial appendage
- direct oral anticoagulants
- transcription factor
- heart failure
- percutaneous coronary intervention
- electronic health record
- hydrogen peroxide
- big data
- high fat diet induced
- machine learning
- type diabetes