In canine bacterial pneumonia circulating granulocyte counts determine outcome from donor cells.

Willard N ApplefeldJeffrey WangJunfeng SunBenjamin M PockrosSteven B SolomonJing FengThomas RisoleoIrene Cortés-PuchAurélie Gouél-CheronHarvey G KleinCharles Natanson

Published in: Transfusion (2020)

During bacterial pneumonia, circulating counts predict the outcome of transfusing granulocytes. With low but normal counts, transfusing granulocytes does not improve survival and injures the lung, whereas for animals with very low counts, but not absolute neutropenia, granulocyte transfusion improves lung function.

Keyphrases

peripheral blood
lung function
cystic fibrosis
chronic obstructive pulmonary disease
induced apoptosis
air pollution
cardiac surgery
cell cycle arrest
cell death
acute kidney injury
respiratory failure
sickle cell disease
acute respiratory distress syndrome
extracorporeal membrane oxygenation