Inducibility or predestination? Queries and concepts around drug-free remission in rheumatoid arthritis.
Bernardo D'OnofrioAnnette van der Helm-van MilThomas Wj HuizingaElise van MulligenPublished in: Expert review of clinical immunology (2022)
The early initiation of DMARD and the subsequent strict monitoring and drug adjustments are of primary importance to allow patients to achieve DFR, irrespective of initial treatment strategy. Once remission is obtained and maintained, it is possible to gradually taper and discontinue drugs with no dramatic consequences on the disease course. Among those who stop medication, ACPA-negative patients more often maintain the remission. Thus, DFR might depend on a combination of intrinsic and extrinsic factors.
Keyphrases
- end stage renal disease
- rheumatoid arthritis
- newly diagnosed
- ejection fraction
- disease activity
- chronic kidney disease
- peritoneal dialysis
- prognostic factors
- healthcare
- emergency department
- systemic lupus erythematosus
- patient reported outcomes
- adverse drug
- ankylosing spondylitis
- interstitial lung disease
- systemic sclerosis
- drug induced
- electronic health record