Silent progression of brain atrophy in aquaporin-4 antibody-positive neuromyelitis optica spectrum disorder.

Hiroki Masuda Masahiro Mori Shigeki Hirano Akiyuki UzawaTomohiko UchidaMayumi MutoRyohei OhtaniReiji AokiSatoshi Kuwabara

Published in: Journal of neurology, neurosurgery, and psychiatry (2021)

Silent progression of brain atrophy was present in patients with AQP4+NMOSD, as shown in patients with MS, even in the clinically inactive age-matched cases. Subclinical dying back degeneration may explain the brain atrophy in patients with AQP4 +NMOSD.

Keyphrases

resting state
white matter
spectrum disorder
functional connectivity
multiple sclerosis
mass spectrometry
palliative care
ms ms