Harnessing the potential of genomic characterization of mutational profiles to improve early diagnosis of lung cancer.
Valerio GristinaFrancesco PepeCarlo GenovaTancredi Didier Bazan RussoAndrea GottardoGianluca RussoLorena IncorvaiaAntonio GalvanoGiuseppe BadalamentiViviana BazanGiancarlo TronconeAntonio RussoUmberto MalapellePublished in: Expert review of molecular diagnostics (2024)
Despite the promising advancements in genomic characterization techniques, several challenges remain, such as the heterogeneity of LC mutations, the high cost, and limited accessibility of Next-Generation Sequencing (NGS) technologies. Additionally, there is a critical need of standardized protocols for interpreting mutational data. Future research should focus on overcoming these barriers to integrate these novel diagnostic methods into standard clinical practice, potentially revolutionizing the management of LC patients.
Keyphrases
- copy number
- end stage renal disease
- clinical practice
- ejection fraction
- chronic kidney disease
- big data
- simultaneous determination
- mass spectrometry
- peritoneal dialysis
- single cell
- current status
- liquid chromatography
- dna methylation
- risk assessment
- solid phase extraction
- high resolution
- patient reported
- circulating tumor cells
- high resolution mass spectrometry