Tuberculosis severity associates with variants and eQTLs related to vascular biology and infection-induced inflammation.
Michael L McHenryJason SimmonsHyejeong HongLaShaunda L MaloneHarriet Mayanja KiizaWilliam S BushW Henry BoomThomas R HawnScott M WilliamsCatherine M SteinPublished in: PLoS genetics (2023)
These analyses reveal new insights into the genetics of TB severity with regulation of platelet homeostasis and vascular biology being central to consequences for active TB patients. This analysis also reveals genes that regulate inflammation can lead to differences in severity. Our findings provide an important step in improving TB patient outcomes.
Keyphrases
- mycobacterium tuberculosis
- oxidative stress
- end stage renal disease
- ejection fraction
- genome wide
- newly diagnosed
- chronic kidney disease
- diabetic rats
- peritoneal dialysis
- high glucose
- pulmonary tuberculosis
- gene expression
- emergency department
- prognostic factors
- dna methylation
- copy number
- stress induced
- human immunodeficiency virus
- patient reported
- endothelial cells