Changes in metabolic hormones and trace elements in CSF in active smokers indicate oxidative damage to brain cells.
Peiwen ZhengFan WangHui LiHanlu ChenMengtong LiHaozheng MaJue HeLi ChenYanlong LiuHaiyun XuPublished in: Endocrine connections (2024)
These data relate smoking-induced weight gain to its neurotoxic effect on the neurons that synthesize metabolic hormones such as adiponectin, ghrelin, leptin, or orexin A in the brain, by disrupting mitochondrial function and causing oxidative stress in the neurons.
Keyphrases
- weight gain
- induced apoptosis
- oxidative stress
- diabetic rats
- resting state
- smoking cessation
- body mass index
- white matter
- birth weight
- spinal cord
- functional connectivity
- cell cycle arrest
- cerebral ischemia
- metabolic syndrome
- endoplasmic reticulum stress
- signaling pathway
- weight loss
- electronic health record
- insulin resistance
- multiple sclerosis
- deep learning
- cell death
- artificial intelligence
- brain injury
- skeletal muscle
- subarachnoid hemorrhage
- pi k akt