Association of Nirmatrelvir/Ritonavir Treatment and COVID-19-Neutralizing Antibody Titers in a Longitudinal Health Care Worker Cohort.

Slade DeckerShaoming XiaoCarly DillenChristina M SchumacherAaron M MilstoneMatthew FriemanAmanda K Debes

Published in: Open forum infectious diseases (2024)

Nirmatrelvir/ritonavir (NMV/r) is used for the treatment of coronavirus disease 2019 (COVID-19) infection. However, rebound COVID-19 infections can occur after taking NMV/r. We examined neutralizing antibodies to the severe acute respiratory syndrome coronavirus 2 spike protein before and after infection in people who did and did not take NMV/r to determine if NMV/r impedes the humoral immune response.

Keyphrases

coronavirus disease
respiratory syndrome coronavirus
sars cov
immune response
healthcare
dengue virus
antiretroviral therapy
small molecule
combination therapy
binding protein
inflammatory response
smoking cessation
protein protein
aedes aegypti