NKG2D Controls Natural Reactivity of Vγ9Vδ2 T Lymphocytes against Mesenchymal Glioblastoma Cells.

Cynthia N Chauvin-FleurenceNoémie JoallandJeanne PerroteauUlrich JarryLaura LafranceCatherine WillemChristelle RetiereLisa OliverCatherine GratasLaetitia Gautreau-RollandXavier SaulquinFrançois M ValletteHenri ViéEmmanuel ScotetClaire Pecqueur

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2019)

By identifying pathways implicated in the selective natural recognition of mesenchymal GBM cell subtypes, accounting for 30% of primary diagnosed and 60% of recurrent GBM, our results pave the way for novel targeted cellular immunotherapies.

Keyphrases

bone marrow
induced apoptosis
stem cells
cell cycle arrest
single cell
cell therapy
oxidative stress
endoplasmic reticulum stress
signaling pathway
natural killer cells
drug delivery