Visceral muscle dysmotility syndrome in systemic lupus erythematosus: which is the role of 18 fluorodeoxyglucose-positron emission tomography-computed tomography? A clinical case and literature review.
Silvia ScriffignanoFabio Massimo PerrottaMaria RicciB CarabelleseEnnio LubranoPublished in: Reumatismo (2024)
Visceral muscle dysmotility syndrome (VMDS) is a rare syndrome, described in the systemic lupus erythematosus (SLE) clinical course. It is characterized by diffuse thickened intestinal wall and gastrointestinal-genitourinary-hepatobiliary hollow viscera dilatation and dysmotility. Due to the rarity and the heterogeneity of the clinical characteristics of this syndrome, it is not entirely clear which is the best diagnostic imaging technique for the diagnosis and/or follow-up, even if, in all the described cases, computed tomography (CT) was generally used to study visceral involvement. However, there are no cases describing the visceral metabolic activity by 18 fluorodeoxyglucose (18FDG)-positron emission tomography-CT (18FDG-PET-CT). Here, we reported the first clinical case of VMDS studied by 18FDG-PET-CT, characterizing the metabolic activity of this rare syndrome during SLE flare. We found a high intestinal metabolic burden, hyper-fixation in duodenum, and high hepatic metabolic activity. Moreover, we reviewed the literature on VMDS in SLE, focusing on imaging techniques in different anatomical sites (bowel, urinary tract, bile ducts), patients' symptoms, and treatment.
Keyphrases
- positron emission tomography
- computed tomography
- systemic lupus erythematosus
- case report
- pet imaging
- dual energy
- pet ct
- magnetic resonance imaging
- disease activity
- image quality
- insulin resistance
- contrast enhanced
- high resolution
- skeletal muscle
- ejection fraction
- end stage renal disease
- type diabetes
- newly diagnosed
- systematic review
- mass spectrometry
- rheumatoid arthritis
- depressive symptoms
- single cell
- minimally invasive
- magnetic resonance
- combination therapy
- peritoneal dialysis
- prognostic factors
- adipose tissue
- highly efficient
- simultaneous determination
- liquid chromatography