Myelination, axonal loss and Schwann cell characteristics in axonal polyneuropathy compared to controls.
Eva GyöriLea Maria BrandstetterJakob Zemann-SchälssSonja WolfChristine RadtkePublished in: PloS one (2021)
This study provided quantitative data of axonal loss, reduced myelination and Schwann cell dysfunction of polyneuropathy patients compared to neurologically healthy controls. Phenotypic alterations of Schwann cells were similar to those seen after peripheral nerve injury, highlighting the clinical relevance of Schwann cell dysfunction.
Keyphrases
- peripheral nerve
- single cell
- spinal cord injury
- cell therapy
- oxidative stress
- end stage renal disease
- ejection fraction
- newly diagnosed
- induced apoptosis
- stem cells
- mesenchymal stem cells
- prognostic factors
- signaling pathway
- big data
- cell cycle arrest
- cell proliferation
- optical coherence tomography
- patient reported
- pi k akt