V1b Receptor Antagonist SSR149415 and Naltrexone Synergistically Decrease Excessive Alcohol Drinking in Male and Female Mice.

Yan ZhouMarcelo RubinsteinMalcolm J LowMary Jeanne Kreek

Published in: Alcoholism, clinical and experimental research (2017)

The combination of V1b antagonist SSR149415 with NTN at individual subthreshold doses shows potential in alcoholism treatment, possibly with less adverse effects.

Keyphrases

alcohol consumption
genetic diversity
weight gain
physical activity
metabolic syndrome
risk assessment
body mass index
insulin resistance
replacement therapy
alcohol use disorder