The Neuropeptide Spexin Promotes the Osteoblast Differentiation of MC3T3-E1 Cells via the MEK/ERK Pathway and Bone Regeneration in a Mouse Calvarial Defect Model.

Freshet AssefaJu Ang KimJiwon LimSang-Hyeon NamHong-In ShinEui-Kyun Park

Published in: Tissue engineering and regenerative medicine (2021)

Overall, these results demonstrated that SPX stimulated osteogenic differentiation in vitro and increased in vivo bone regeneration via the MEK/ERK pathway.

Keyphrases

bone regeneration
pi k akt
cell cycle arrest
signaling pathway
induced apoptosis
cell proliferation
mesenchymal stem cells
bone marrow
oxidative stress
endoplasmic reticulum stress