Effects of COX1-2/5-LOX blockade in Alzheimer transgenic 3xTg-AD mice.

Alessandra BittoDaniela GiulianiGiovanni PallioNatasha IrreraEleonora VandiniFabrizio CanaliniDavide ZaffeAlessandra OttaniLetteria MinutoliMariagrazia RinaldiSalvatore GuariniFrancesco SquadritoDomenica Altavilla

Published in: Inflammation research : official journal of the European Histamine Research Society ... [et al.] (2017)

Pharmacological blockade of both COX-1/2 and 5-LOX was able to counteract the progression of AD by targeting pathophysiological mechanisms up- and downstream of Aβ and tau.

Keyphrases

low density lipoprotein
cognitive decline
high fat diet induced
cerebrospinal fluid
metabolic syndrome
mild cognitive impairment