Pleomorphic fibroma of the skin with MDM2 immunoreactivity: A potential diagnostic pitfall.
Mehrnoosh TashakoriJason PimentelBrooke E HowittJessica SanchezSusan MichalowskiDhananjay ChitaleAdrian H OrmsbySean R WilliamsonPublished in: Journal of cutaneous pathology (2017)
Pleomorphic fibroma is a rare benign cutaneous neoplasm characterized by spindle-shaped cells and multinucleated giant cells scattered throughout collagenous stroma. These morphologic features can lead to diagnostic confusion, including atypical lipomatous tumor as one consideration. In contrast to atypical lipomatous tumor, previous studies have found pleomorphic fibroma to be negative for MDM2 immunohistochemical staining and MDM2 gene amplification. Here, we present a case of pleomorphic fibroma of skin with nuclear MDM2 immunoreactivity in the absence of MDM2 gene amplification, underscoring the superiority of fluorescence in situ hybridization as a diagnostic test in this differential diagnosis. The RB1 locus is also explored for differential diagnosis with pleomorphic/spindle cell lipoma and related entities.
Keyphrases
- induced apoptosis
- cell cycle arrest
- copy number
- genome wide
- magnetic resonance
- soft tissue
- nucleic acid
- endoplasmic reticulum stress
- gene expression
- oxidative stress
- computed tomography
- low grade
- cell death
- magnetic resonance imaging
- cell proliferation
- dna methylation
- genome wide identification
- bone marrow
- mesenchymal stem cells
- risk assessment
- transcription factor
- single molecule
- human health